He had a great NFL career, mostly with the Buffalo Bills, where he was selected to many Pro Bowls and won running crowns.
Simpson gained popularity on television after featuring in ads for companies like Hertz, in which he hurried through airports, then going on to feature in films.
Following the horrific killings of Ronald Goldman and Nicole Brown Simpson in 1994, Simpson was taken into custody and a nationally broadcast low-speed vehicle pursuit ensued.
Even with all of the drama and legal wrangling, Simpson's legacy is still entwined with football legend and shame.